What is Butyrfentanyl HCL ?
Above all Butyrfentanyl HCL or butyrylfentanyl is a potent short-acting synthetic opioid analgesic drug. However it is an analog of fentanyl with around one quarter of its potency. For instance one of the first mentions of this drug can be found in document written by The College on Problem of Drug Dependence. Where it mentioned as N-butyramide fentanyl analog. This document also states that the article describing its clinical effects (analgesic studies, μ-, δ-, κ-opioid receptor binding. And in vitro measures of drug efficacy, antinociceptive, and narcotic properties) published in 1987. It is an agonist for the μ-opioid receptors. Butyrfentanyl has no current legitimate clinical applications; however, it is being sold as designer drug. Side effects of fentanyl analogs are similar to those of fentanyl itself, which include itching, nausea. And potentially serious respiratory depression which can be life-threatening. Butyrfentanyl HCL Online
BUTYRFENTANYL HCL PHARMACOKINETICS Butyrfentanyl HCL Online
It binds to the opioid receptor. During the studies of in vitro inhibition of specific fentanyl binding to the opioid receptor, the order of analogues was: cis-3-methylfentanyl > fentanyl = alpha-methylfentanyl > butyrylfentanyl > benzylfentanyl. The studies in inhibition studies on binding affinity achieved the same order of analogues. It means that butyrfentantyl is a less potent opioid-agonist than fentanyl. On the other side, during in vitro studies of cross-reactivity with the fentanyl antibody between fentanyl and the fentanyl analogs examined, revealed order: fentanyl = butyrylfentanyl > (±)-cis-3-methylfentanyl > benzylfentanyl > alpha-methylfentanyl. High cross-reactivity may be the effect of the shape of the molecule. The shape of Butyrfentanyl HCL is closest to the original fentanyl molecule. Which makes it easy to bind by fentanyl antibodies.
The opioid receptor affinity of fentanyl and its analogs determined from their inhibitory potency in a binding assay with fentanyl as the radioligand. The Ki value for Butyrfentanyl HCL was Ki=32 ± 4.1 nM. Comparing to fentanyl’s Ki (Ki=1.06 ± 0.15 nM), butyrfentanyl’s ability to displace [3H] fentanyl is low and it requires high concentrations of the drug.
Studies on urinary excretion revealed that almost all of the injected Butyrfentanyl HCL excreted or metabolized within the first 3 h after injection. And only very low concentrations were still detectable after 3 h. Urinary concentrations of butyrylfentanyl from animals injected with 15 μg/kg and 45 μg/kg i.v. measured by two techniques: radioreceptorassay and gas chromatography/mass spectrometry (GC/MS).